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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 240-262 doi: 10.1007/s11684-022-0936-z
Keywords: glioma progression molecular classification EM/PM subtyping intratumor heterogeneity
Frontiers of Medicine doi: 10.1007/s11684-023-1017-7
Keywords: single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 143-155 doi: 10.1007/s11684-022-0929-y
Keywords: RGS16 let-7c-5p glioma proliferation migration
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 551-561 doi: 10.1007/s11684-020-0760-2
Keywords: glioma evolution mechanism strategies tumor heterogeneity secondary glioma
Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy
TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 49-53 doi: 10.1007/s11684-007-0010-x
Keywords: GFAP-Baxα BT325 Fibrillary apoptotic specificity
Progress on molecular biomarkers and classification of malignant gliomas
Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 150-156 doi: 10.1007/s11684-013-0267-1
Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.
Keywords: malignant glioma molecular biomarker IDH1 MGMT molecular classification
Experimental study on BPA uptake of glioma cell lines
Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui
Strategic Study of CAE 2012, Volume 14, Issue 8, Pages 85-90
Objective: to evaluate the incorporation of BPA by glioma cell lines,cells was increasing with the increasing concentration of BPA, and the boron concentration ratios of gliomaConclusion: BPA has a selectivity for glioma cells, and the results of the efflux assay confirm the temperature
Keywords: boron neutron capture therapy BPA glioma cell line ICP AES
Boron neutron capture therapy for glioblastoma of prospects and confused
Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei
Strategic Study of CAE 2012, Volume 14, Issue 8, Pages 82-84
Boron neutron capture therapy (BNCT) is a selective radiotherapy of damage tumor cells, and α particle produced by which is effective to prevent glioblastoma multiform recurrence. Clinical trails of BNCT were carried out in fifties to sixties of 20 century in developed countries, but it was limited because of the development of boron carrier and neutron source. This is a review of BNCT prospect on glioblastoma multiform.
Keywords: boron neutron capture therapy glioblastoma multiform glioma stem cells
R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander
Engineering 2015, Volume 1, Issue 3, Pages 344-350 doi: 10.15302/J-ENG-2015077
Convection-enhanced delivery (CED) is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6% (w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantified using a custom shadowgraphy setup and image-processing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof-of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating (1064 nm at 500 mW) showed a similar effect with a 3.5-fold increase at 4 h over the control (0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.
Keywords: near-infrared laser thermochemotherapy agarose photothermal heating micro-catheter malignant glioma
Title Author Date Type Operation
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
Journal Article
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell
Journal Article
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
Journal Article
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
Journal Article
Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy
TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo
Journal Article
Progress on molecular biomarkers and classification of malignant gliomas
Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang
Journal Article
Experimental study on BPA uptake of glioma cell lines
Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui
Journal Article
Boron neutron capture therapy for glioblastoma of prospects and confused
Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei
Journal Article